the effects of urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced wistar rats

background and aims: urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type 2 diabetes and decrease inflammation, fibrosis and necrosis as the signs of nonalcoholic steatohepatitis. polycystic ovary syndrome (pcos) as the most important factor of infertility has an overlap of 30 % to 60% with liver disorders. hence, the urtica dioica moderator effect on liver function in pcos rats was examined. methods: in this experimental study 144 adult wistar rats were divided into control, pcos and nettle-treated groups. the group pcos was injected subcutaneously 2 mg estradiol valerate, after 60 days and confirmed polycystic, the experimental group was injected intraperitoneally the urtica dioica extract doses (150,250, 450 mg/kg bw). after 21 days, rats were anesthetized by chloroform; blood samples and livers were collected for histological and serological evaluation. data were analyzed using instat3 via anova one-way and p